GMAC: Genomic Mediation Analysis with Adaptive Confounding Adjustment
Performs genomic mediation
analysis with adaptive confounding adjustment (GMAC) proposed by Yang et al. (2017) <doi:10.1101/078683>. It implements large scale
mediation analysis and adaptively selects potential confounding variables to
adjust for each mediation test from a pool of candidate confounders. The package
is tailored for but not limited to genomic mediation analysis (e.g., cis-gene
mediating trans-gene regulation pattern where an eQTL, its cis-linking gene
transcript, and its trans-gene transcript play the roles as treatment, mediator
and the outcome, respectively), restricting to scenarios with the presence of
cis-association (i.e., treatment-mediator association) and random eQTL (i.e.,
treatment).
| Version: |
3.1 |
| Depends: |
parallel |
| Published: |
2022-03-17 |
| DOI: |
10.32614/CRAN.package.GMAC |
| Author: |
Fan Yang, Jiebiao Wang and Lin Chen |
| Maintainer: |
Jiebiao Wang <randel.wang at gmail.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL] |
| NeedsCompilation: |
no |
| CRAN checks: |
GMAC results |
Documentation:
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