rxode2: Facilities for Simulating from ODE-Based Models
Facilities for running simulations from ordinary differential equation ('ODE') models, such as pharmacometrics and other compartmental models. A compilation manager translates the ODE model into C, compiles it, and dynamically loads the object code into R for improved computational efficiency. An event table object facilitates the specification of complex dosing regimens (optional) and sampling schedules. NB: The use of this package requires both C and Fortran compilers, for details on their use with R please see Section 6.3, Appendix A, and Appendix D in the "R Administration and Installation" manual. Also the code is mostly released under GPL. The 'VODE' and 'LSODA' are in the public domain. The vendored 'SUNDIALS' 'CVODE' sources and headers are released under the BSD-3-Clause license. The information is available in the inst/COPYRIGHTS.
| Version: | 5.1.5 |
| Depends: | R (≥ 4.1.0) |
| Imports: | PreciseSums (≥ 0.7), Rcpp (≥ 0.12.3), RcppParallel, backports, cli (≥ 2.0.0), checkmate, ggplot2 (≥ 3.4.0), inline, lotri (≥ 1.0.4), memoise, methods, mirai, rex, sys, tools, utils, dparser (≥ 1.3.1-12), qs2, rxode2ll, data.table (≥ 1.12.4), vctrs, stats |
| LinkingTo: | sitmo, lotri (≥ 1.0.0), PreciseSums (≥ 0.7), Rcpp, RcppArmadillo (≥ 0.9.300.2.0), BH, RcppParallel, RcppEigen (≥ 0.3.3.9.2), dparser (≥ 1.3.1-12), StanHeaders (≥ 2.21.0.7) |
| Suggests: | Matrix, DT, covr, crayon, curl, digest, dplyr (≥ 0.8.0), ggrepel, gridExtra, htmltools, knitr, learnr, microbenchmark, nlme, remotes, rlang, rmarkdown, scales, shiny, stringi, symengine, testthat, tidyr, usethis, withr, xgxr, pillar, tibble, units (≥ 0.6-0), rsconnect, devtools, patchwork, nlmixr2data, lifecycle, kableExtra, pmxTools, rootSolve, arrow, fst, duckdb, DBI |
| Published: | 2026-07-28 |
| DOI: | 10.32614/CRAN.package.rxode2 |
| Author: | Matthew L. Fidler 
[aut, cre],
Wenping Wang [aut],
Aaron Collier [ctb] (SUNDIALS/CVODE),
Alan Hindmarsh [ctb],
Arun Srinivasan [ctb],
Ashley Crawford [ctb] (SUNDIALS/CVODE),
Awad H. Al-Mohy [ctb],
Bill Denney [ctb],
Cleve Moler [ctb],
Cody J. Balos [ctb] (SUNDIALS/CVODE),
Dan Shumaker [ctb] (SUNDIALS/CVODE),
Daniel Kaschek [ctb],
Daniel R. Reynolds [ctb] (SUNDIALS/CVODE),
David Cooley [ctb],
David J. Gardner [ctb] (SUNDIALS/CVODE),
Drew Schmidt [ctb],
Ernst Hairer [ctb],
Gabriel Staples [ctb],
Gerhard Wanner [ctb],
Gilbert Stewart [ctb],
Goro Fuji [ctb],
Hadley Wickham [ctb],
Hidde van de Beek [ctb],
Igor Kushnir [ctb],
Imperial College of Science, Technology and Medicine [cph],
Jack Dongarra [ctb],
Jacob Williams [ctb],
Jim Bunch [ctb],
Karline Soetaert [ctb],
Kevin Ushey [ctb],
Lawrence Livermore National Security [cph] (SUNDIALS/CVODE),
Linda Petzold [ctb],
Mark M. Baum [ctb],
Martin Maechler [ctb],
Matt Dowle [ctb],
Matteo Fasiolo [ctb],
Melissa Hallow [aut],
Michel Lang [ctb],
Morwenn [ctb],
Nicholas J. Higham [ctb],
Omar Elashkar [ctb],
Peter N. Brown [ctb],
Radu Serban [ctb] (SUNDIALS/CVODE),
Rich FitzJohn [ctb],
Richard Upton [ctb],
Roger B. Sidje [ctb],
Scott D. Cohen [ctb] (SUNDIALS/CVODE),
Simon Frost [ctb],
Slaven Peles [ctb] (SUNDIALS/CVODE),
Southern Methodist University [cph] (SUNDIALS/CVODE),
Thomas Petzoldt [ctb],
University of Maryland Baltimore County [cph] (SUNDIALS/CVODE),
Wes Hinsley [ctb],
Woodrow Setzer [ctb],
Yu Feng [ctb],
Zufar Mulyukov [ctb] |
| Maintainer: | Matthew L. Fidler <matthew.fidler at gmail.com> |
| BugReports: | https://github.com/nlmixr2/rxode2/issues/ |
| License: | GPL (≥ 3) |
| Copyright: | see file COPYRIGHTS |
| URL: | https://nlmixr2.github.io/rxode2/, https://github.com/nlmixr2/rxode2/ |
| NeedsCompilation: | yes |
| Language: | en-US |
| Citation: | rxode2 citation info |
| Materials: | README, NEWS |
| In views: | DifferentialEquations, HighPerformanceComputing, MixedModels, Pharmacokinetics |
| CRAN checks: | rxode2 results |
Documentation:
| Reference manual: | rxode2.html , rxode2.pdf |
| Vignettes: |
rxode2 ODE solving syntax (source) |
Downloads:
| Package source: | rxode2_5.1.5.tar.gz |
| Windows binaries: | r-devel: rxode2_5.1.4.zip, r-release: rxode2_5.1.4.zip, r-oldrel: rxode2_5.1.4.zip |
| macOS binaries: | r-release (arm64): rxode2_5.1.4.tgz, r-oldrel (arm64): rxode2_5.1.4.tgz, r-release (x86_64): rxode2_5.1.4.tgz, r-oldrel (x86_64): rxode2_5.1.4.tgz |
| Old sources: | rxode2 archive |
Reverse dependencies:
| Reverse imports: | admixr2, babelmixr2, monolix2rx, nlmixr2, nlmixr2auto, nlmixr2autoinit, nlmixr2est, nlmixr2extra, nlmixr2lib, nlmixr2plot, nlmixr2rpt, nlmixr2save, nlmixr2targets, nonmem2rx, posologyr, shinyMixR, SimuRg |
| Reverse linking to: | babelmixr2, monolix2rx, nlmixr2est, nonmem2rx |
| Reverse suggests: | amp.sim, campsis, ggPMX, PKbioanalysis, pmxNODE, ruminate, rxode2mrgsolvebridge, ubiquity, xpose.xtras |
Linking:
Please use the canonical form https://CRAN.R-project.org/package=rxode2 to link to this page.