SATS: Signature Analyzer for Targeted Sequencing

SATS stands for Signature Analyzer for Targeted Sequencing and performs mutational signature analysis for targeted sequenced tumors. Unlike the canonical analysis of mutational signatures, SATS factorizes the mutation counts matrix into a panel context matrix (measuring the size of the targeted sequenced genome for each tumor in the unit of million base pairs (Mb)), a signature profile matrix, and a signature activity matrix. SATS also calculates the expected number of mutations attributed by a signature, namely signature burden, for each targeted sequenced tumor. For more details see Lee et al. (2024) <doi:10.1101/2023.05.18.23290188>.

Version:	1.0.10
Depends:	R (≥ 4.1.0)
Imports:	stats, glmnet, GenomicRanges, IRanges, Biostrings, dplyr
Suggests:	testthat, BSgenome.Hsapiens.UCSC.hg19, BSgenome.Hsapiens.UCSC.hg38
Published:	2026-07-09
DOI:	10.32614/CRAN.package.SATS
Author:	DongHyuk Lee [aut], Bin Zhu [aut], Bill Wheeler [cre]
Maintainer:	Bill Wheeler <wheelerb at imsweb.com>
License:	GPL-2
NeedsCompilation:	yes
CRAN checks:	SATS results

Documentation:

Reference manual:

SATS.html , SATS.pdf

Downloads:

Package source:	SATS_1.0.10.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): not available, r-oldrel (x86_64): not available
Old sources:	SATS archive

Linking:

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